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While hypogonadism is the most common change in the pituitary-gonadal axis, CPP, though rare, has been documented in children with PWS and could be linked to loss-of-function variations in the MKRN3 gene at the 15q11-q13 locus (228, 229)

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It continued accelerating between 48 and 68 weeks, suggesting the full effect may not yet have been reached even at the trial endpoints